Histidine-rich glycoprotein (HRG), a 75 kDa plasma protein primarily produced by the liver,has multiple functions. HRG regulates angiogenesis, coagulation/fibrinolysis, host defenses,dead cell clearance and tumor growth (17).
富含組氨酸的糖蛋白 (HRG) 是一種主要由肝臟產生的 75 kDa 血漿蛋白,具有多種功能。
HRG 調節血管生成、凝血/纖溶、宿主防禦、死細胞清除和腫瘤生長 (17)。
These results from models of animal sepsis and the clinical findings suggest that decreases in HRG and IAIPs concentrations could represent excellent biomarkers to evaluate the severity of sepsis mainly caused by bacterial infections (25, 30).
這些來自動物膿毒症模型的結果和臨床發現表明 HRG 和 IAIPs 濃度的降低可能是評估主要由細菌感染引起的膿毒症嚴重程度的極好生物標誌物 (25, 30)。
A clinical study demonstrated that the plasma levels of HRG were lower in non-survivors than in survivors on the admission day in ICU patients (19).
一項臨床研究表明,在 ICU 患者入院當天,非倖存者的血漿 HRG 水平低於倖存者 (19)。
The findings of the protection of vascular endothelial cells by HRG (23) as well as IAIPs (33), and the prevention of platelet aggregation by IAIPs (31) and erythrocyte aggregation by HRG (43) support the functional role of these plasma proteins against venous thromboembolism.
HRG (23) 和 IAIPs (33) 保護血管內皮細胞以及 IAIPs (31) 防止血小板聚集和 HRG (43) 防止紅細胞聚集的發現支持這些血漿蛋白的功能作用靜脈血栓栓塞症。
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Michael Acceptors Tuned by the Pivotal Aromaticity of Histidine to Block COVID-19 Activity
通過組氨酸的關鍵芳香性調節邁克爾受體以阻止 COVID-19 活性